Drug for cancer treatment is effective against eye flu-timer Naturopathy naturopathy specialist portal

Drug for cancer treatment is effective against eye flu-timer Naturopathy naturopathy specialist portal

Arsenic trioxide against adenoviruses

Adenoviruses can cause eye flu, gastro-intestinal disorders or lung inflammation. In most people, infection is relatively harmless, but in people with a weakened immune system there may be gradients of serious and even fatal Infection. Researchers now report that a drug for cancer treatment against the virus could help.

According to a recent communication from an infection with adenoviruses can be life-particularly for children following a stem cell transplant dangerous. Researchers from the Technical University of Munich (TUM) and the Helmholtz Zentrum München have now succeeded in showing that an already-approved drug to treat cancer could help against the virus infection. Due to the special mechanism of action of the drug, the Virus can develop defense strategies.

Mostly a harmless course of Infection

As the country centre for health North Rhine-explains Westphalia, in a leaflet, are infections common with adenoviruses in the world, by no means rare, and occur every Season, however, only in people. Often it comes to fixed evolution to Occur. The viruses are very environmentally resistant and can remain at room temperature for weeks contagious.

The infective conjunctiva and inflammation of the cornea of the eye, also eyes the flu is caused by adenovirus. In addition, the pathogens of the gastro-intestinal cause inflammation-symptoms or even lung. In the majority of cases of a disease in healthy adults, although it runs without or with mild symptoms.

“Every adult has usually been several Adenovirus-infections,” says Dr. Sabrina carpenter. The scientist works at the Institute for Virology at the TUM and the Helmholtz Zentrum München. The human virus, of which there are currently more than 85 different variants that previously were not considered particularly dangerous.

No drug or vaccine available

However, according to the TUM, it can occur in people with a weakened immune system to severe and even fatal courses of the infection. A particularly dangerous disease for children following a stem cell transplant. In infected patients, the mortality in this case is the according to the experts, even at 80 percent.

“Since 2006 we know, moreover, that even in healthy people, infections with adenoviruses occur, the severity of lung inflammation can cause death,” says Schreiner. So far, no drug that acts specifically against adenovirus does not yet exist. Vaccinations for the normal population, there is not yet also.

Anti-Viral Function

The Virological and virologists study how the Virus replicates in the cell. The researchers had observed that the so-called PML-nuclear body, a complex of several proteins in the cell, change in the case of infection with adenoviruses strong. According to the figures, the otherwise round structures are dissolving, resulting in elongated fibrils.

“It is believed that the PML-nuclear bodies have anti-viral function,” explains carpenter. “The virus will destroy the round structures of the protein complexes, and use this Manipulation of the cell for its own reproduction.”

Strengthening the body’s own defense

The research team of carpenters noticed that in the case of Cancer patients, the structures of the PML-nuclear bodies were also dissolved. The Patients were treated with ATO (arsenic trioxide), were the round structures.

“It is in the ATO, a well-known substance, which is approved and in the clinic as a whole is currently suffering from Leukaemia is to be used”, explains the scientist.

The researchers tested the effect of the drug in adenovirus-infected cell cultures. In fact, the PML-nuclear bodies formed again, round structures, and the virus concentration decreased. “So, we can actually make this body’s own anti-viral factories, which fight the Virus, then,” said Schreiner.

The results of the scientists were published in the journal “Advanced Science”.

Doesn’t work directly against the Virus

After the Test, in the laboratory, the drug should be used in the next step also in the case of adenovirus-infected patients. The research team is in contact with children’s physicians in Munich clinics. Because the drug is already approved, it can be used directly for the treatment.

“It is a arsenic-containing compound, but in the concentrations in which it is used, and already is approved, it has no cell toxic side effects,” explains carpenter.

The peculiarity of this drug: It acts on the cell’s own structures, directly against the Virus. “It is often the case that viruses develop resistance to drugs that attack you directly,” says Schreiner. “For example, you can mutate so that they are no longer recognized by the drug. Since the Virus has in this case, but no direct interaction with the active ingredient, it can develop mechanisms of defense.“ (ad)

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