For an embryo to survive, it must attach to the lining of the uterus within days of conception. However, if this lining, called the endometrium, is too thin, the embryo can’t latch on. Now, researchers reporting in ACS Biomaterials Science & Engineering have developed a new system intended to treat infertility in women with thin endometria. Their tiny, micro-scale particles stimulated blood vessel growth, producing promising results in preliminary experiments in cells and mice.
Poor blood flow within the endometrium limits its thickness, and researchers have struggled to find an effective way to encourage the formation of new blood vessels. Some have begun exploring the use of microspheres to deliver treatment. However, current methods for making these tiny particles face challenges, including the need for complex, demanding production methods and too much variation in the sizes of the spheres. So, Xiangguo Wang, Lei Yang and their colleagues wanted to devise a simple, efficient technique for manufacturing uniform microspheres loaded with a compound known to be a potent stimulator of blood vessel growth.
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