- Obesity and overweight are widespread globally and increase the risk of many health conditions.
- A new injectable treatment, semaglutide, has just been recommended for use in the United Kingdom.
- In a study, those on the treatment lost, on average, almost 15% of their body mass.
- The injections could help those who wish to achieve a moderate weight.
The World Health Organization (WHO) defines overweight and obesity as: “abnormal or excessive fat accumulation that may impair health.”
Worldwide, obesity rates have almost tripled since 1975, and they are still increasing. In 2018, the Centers for Disease Control and Prevention (CDC) defined obesity as a BMI of 30 or higher and stated that 42.4% of adults in the United States had obesity. In 2019, 27% of males and 29% of females in the U.K. had obesity.
Obesity increases the risk of many health conditions, among them:
- heart disease
- type 2 diabetes
- certain types of cancer, including breast, kidney, liver, and colon.
Many people find it challenging to achieve and maintain a moderate weight. The National Institue for Health and Care Excellence (NICE) has recommended a weight loss injection for use in the U.K. by the National Health Service NHS). However, the U.K. regulatory bodies have yet to fully approve the treatment. The Food and Drug Administration (FDA) approved the treatment last year.
The drug, semaglutide, brand name Wegovy, mimics the hormone glucagon-like peptide-1, which the body releases after eating. The treatment makes people feel fuller, so they do not get so hungry and eat less.
In a 2021 trial, 1,961 adults with a BMI over 30 (mean 37.9) were allocated in a 2:1 ratio to treatment with semaglutide or placebo. The treatment group self-administered weekly injections of 2.4 milligrams (mg) of semaglutide; the control group received a placebo in the same way.
The trial was double-blind — neither the participants nor the researchers knew which group each other was in.
All those taking part in the trial also followed a reduced calorie diet and increased their physical activity. They received counseling sessions every 4 weeks to help them maintain the lifestyle changes.
Significant weight loss
The results were striking. In the treatment group, participants lost, on average, 14.9% of their body mass over the 68 weeks of the trial. Those receiving placebo reduced their weight by 2.4% on average.
Kristin Kirkpatrick, a registered dietitian nutritionist at the Cleveland Clinic, told Medical News Today she welcomed the results: “Any advance to help individuals to reduce their risk for common chronic conditions is a good thing.”
Just over half of those in the treatment group lost more than 15% of their body weight compared with 4.9% of the placebo group. People in both groups reported some mild to moderate side effects, such as diarrhea, flatulence, and indigestion.
However, despite these side effects, none of the participants discontinued the treatment.
Who can get the treatment?
Semaglutide has been recommended for only some people with obesity, as many can achieve and maintain a moderate weight through diet and exercise.
NICE recommends that specialists prescribe the drug for people who have a BMI of more than 35, and at least one weight-related health condition, such as hypertension, type 2 diabetes, or coronary heart disease. They may prescribe it to people with a BMI lower than 35 in exceptional circumstances.
NICE also states that a specialist must prescribe the drug as part of a weight-management program and for a maximum of 2 years.
Could the drug be an alternative to bariatric surgery for losing weight? Dr. Mir Ali, bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, CA, told MNT he was not convinced: “No medical treatment options have been shown to be as effective, either short or long term, as surgical weight loss for those who meet criteria for surgery.”
Experts question whether this drug is a long-term solution for those trying to achieve and maintain a moderate weight. One trial participant, who lost 22% of her body weight during the trial, found that her appetite returned once she stopped the injections, and she is gaining weight.
“Now that I am no longer taking the drug, unfortunately, my weight is returning to what it used to be. It felt effortless losing weight while on the trial, but now it has gone back to feeling like a constant battle with food. I hope that, if the drug can be approved for people like me, my [doctor] will be able to prescribe the drug for me in the future.”
“All weight-loss strategies require sustained lifestyle changes; otherwise, most people will regain most, if not all, the weight they lost. If there is a shift to thinking of obesity more like a chronic disease, such as diabetes or hypertension, then better long-term medication options need to be developed.”
– Dr. Mir Ali.
Kirkpatrick echoed these concerns: “What I would like to see is the long-term data on long-term weight loss maintenance. Many of the patients I see need to not only change the way they are eating, but they need to change their relationship with food as well. Weight loss is hard, but keeping it off can be even harder.”
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